Publication details
Pět nejvýznamnějších lékových interakcí v intenzivní medicíně
| Title in English | Five most important drug interactions in the critically ill |
|---|---|
| Authors | |
| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | Anesteziologie a intenzivní medicína |
| MU Faculty or unit | |
| Citation | |
| Web | https://aimjournal.cz/artkey/aim-202304-0003_five-most-important-drug-interactions-in-the-critically-ill.php?l=cz |
| Doi | http://dx.doi.org/10.36290/aim.2023.053 |
| Keywords | drug interactions; critical care; drug side effects; long QT syndrome; cytochrome P-450 enzyme enhibitors |
| Attached files | |
| Description | The prevalence of drug interactions in the critically ill is high, but these are often potential drug interactions of limited clinical relevance. This paper aims to describe the mechanism and management of not the most frequent but, according to the authors, the most clinically significant interactions. These top five interactions include carbapenems and valproate, CYP 3A4 inhibitors and ticagrelor, enteral nutrition and levodopa, combinations of QT prolonging drugs, and CYP 3A4 inhibitors and quetiapine. |