Publication details
Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy
| Authors | |
|---|---|
| Year of publication | 2024 |
| Type | Article in Periodical |
| Magazine / Source | COMMUNICATIONS CHEMISTRY |
| MU Faculty or unit | |
| Citation | KEJIK, Zdenek, Jan HAJDUCH, Nikita ABRAMENKO, Frederic VELLIEUX, Katerina VESELA, Jindriska LEISCHNER FIALOVA, Kateřina PETRLÁKOVÁ, Katerina KUCNIROVA, Robert KAPLANEK, Ameneh TATAR, Marketa SKALICKOVA, Michal MASAŘÍK, Petr BABULA, Petr DYTRYCH, David HOSKOVEC, Pavel MARTASEK and Milan JAKUBEK. Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy. COMMUNICATIONS CHEMISTRY. BERLIN: NATURE PORTFOLIO, 2024, vol. 7, No 1, p. 1-39. ISSN 2399-3669. Available from: https://dx.doi.org/10.1038/s42004-024-01256-6. |
| web | https://www.nature.com/articles/s42004-024-01256-6 |
| Doi | http://dx.doi.org/10.1038/s42004-024-01256-6 |
| Keywords | cyanine dyes; mitochondria-targeting photodynamic therapy; photothermal therapy |
| Attached files | |
| Description | Mitochondrial dysregulation plays a significant role in the carcinogenesis. On the other hand, its destabilization strongly represses the viability and metastatic potential of cancer cells. Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show significant potential in enhancing PDT and PTT. The potential and limitations of cyanine dyes for mitochondrial PDT and PTT are discussed, along with their applications in combination therapies, theranostic techniques, and optimal delivery systems. Additionally, novel approaches for sonodynamic therapy using photoactive cyanine dyes are presented, highlighting advances in cancer treatment. |
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