Publication details
Farmakologická zátěž regadenosonem při konvenčním i dynamickém SPECT myokardu
| Title in English | Pharmacological stress test using regadenoson in conventional and dynamic cardiac SPECT |
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| Authors | |
| Year of publication | 2024 |
| Type | Article in Periodical |
| Magazine / Source | Intervenční a akutní kardiologie |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.iakardiologie.cz/artkey/kar-202401-0009_farmakologicka_zatez_regadenosonem_pri_konvencnim_i_dynamickem_spect_myokardu.php |
| Doi | http://dx.doi.org/10.36290/kar.2024.001 |
| Keywords | regadenoson; cardiac SPECT; dynamic SPECT; MBF; CFR |
| Description | Regadenoson as a selective A2A adenosine enables pharmacological stress when exercise stress techniques would be impossible or very difficult. We present two case reports demonstrating its advantages. In case 1, we initially attempted to induce stress using physical exercise in a 77-year-old male patient after coronary artery bypass graft. Due to inadequate heart rate increase, the stress was promptly converted to pharmacological stress using regadenoson in combination with a low level of exercise. Single-photon emission computed tomography (SPECT) showed extensive ischaemia of the lateral wall. Coronary angiography subsequently revealed vein graft occlusion at the left circumflex artery. Case 2 demonstrates recent advances in SPECT technology. Modern multidetector Cadmium Zinc Telluride (CZT) cameras enable dynamic acquisition and quantification of coronary flow reserve (CFR). It can be helpful in identifying multivessel disease or microvascular ischaemia. CFR is calculated as the ratio between myocardial blood flow during stress vasodilator hyperaemia and flow at rest. In a 50-year-old diabetic patient, a conventional cardiac SPECT showed normal post-stress left ventricular perfusion and function. Dynamic SPECT showed normal myocardial blood flow (MBF) and normal CFR ? 2. During 18 months of follow-up, no cardiac event was observed in this patient. |