Publication details
Střevní mikrobiom u nemocných s chronickou pankreatitidou
| Title in English | Intestinal microbiome in patients with chronic pancreatitis |
|---|---|
| Authors | |
| Year of publication | 2024 |
| Type | Article in Periodical |
| Magazine / Source | Gastroenterologie a hepatologie |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.prolekare.cz/casopisy/ceska-slovenska-gastro/2024-3-7/intestinal-microbio-me-in-patients-with-chronic-pancreatitis-137933 |
| Doi | http://dx.doi.org/10.48095/ccgh2024242 |
| Keywords | intestinal microbiome; chronic pancreatitis; autoimmune pancreatitis; diabetes mellitus; exocrine pancreatic insufficiency; corticoids |
| Description | We refer to the microflora inhabiting the intestine as a whole as the intestinal microbiota, and their genomes collectively as the microbiome. Dysbiosis is a violation of the balance between the intestinal microbiota, the immune system and the epithelial intestinal barrier. Dysbiosis is associated not only with a number of gastrointestinal diseases, including inflammatory and cancerous diseases of the pancreas. We do not know the answer as to whether dysbiosis is a causal factor in the development of chronic pancreatitis, but it is a fact that, for example, the severity of the disease or changes in exocrine or endocrine pancreatic function are related to the intestinal microbiota. Pancreatic enzymes, especially pancreatic elastase, are significantly involved in the modulation of intestinal microflora. Specific changes in the composition of the intestinal microbiome in people with an autoimmune form of chronic pancreatitis could also become early diagnostic markers of the disease. It is evident that systematic research is more than desirable in this area of pancreatology. |