Publication details
In vitro study of materials for functional replacements in nerve tissue regeneration
| Authors | |
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| Year of publication | 2024 |
| Type | Appeared in Conference without Proceedings |
| Citation | |
| Description | Sciatic nerve injuries pose a significant clinical challenge, often resulting in severe functional impairment and reduced quality of life. Precise 3D printing fabrication of scaffolds that replicate the complex architecture of native nerve tissue emerges as a promising solution for further nerve tissue regeneration. Schwann cells play a crucial role in supporting neurons by promoting axonal growth and facilitating myelination, which is essential for effective nerve regeneration. This study focuses on printable polymer-based biocompatible materials, enabling Schwann cell adhesion, proliferation, and differentiation in vitro. The growth of cells and the extension of cell processes were evaluated using immunocytochemistry for beta-actin. Among the tested materials, the initial synthetic biocompatible material demonstrated low cell adhesion, resulting in poor cell viability on the surface. In contrast, the enhanced composite scaffolds seem to be more suitable, supporting better cell growth and cell process extension. Our results provide a platform of suitable materials for the growth of Schwann cells. These findings offer a promising foundation for further research and development of complex conduits for nerve tissue regeneration. |
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