Publication details

The role of coatings and plasticizers compatibility in stability of advanced gastro-resistant self-emulsifying pellets designed for the delivery of volatile compounds: A combined solid-state NMR and dissolution study

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Authors

MACKŮ Jan VYSLOUŽIL Jakub MUSELÍK Jan PAVELKOVÁ Miroslava VETCHÝ David HLAVATÁ Daniela MIROSLAV Šlouf ČUBOVÁ URBANOVÁ Martina BRUS Jiří KUBOVÁ Kateřina

Year of publication 2024
Type Article in Periodical
Magazine / Source JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
MU Faculty or unit

Faculty of Pharmacy

Citation
Web https://www.sciencedirect.com/science/article/pii/S1773224724009948
Doi http://dx.doi.org/1016/j.jddst.2024.106325
Keywords Self-emulsifying pellets; Eudragit® L 30 D-55; Triethyl citrate; Plasticizer; Thymol; Stability
Description The gastro-resistant behaviour of solid self-emulsifying drug delivery systems (S-SEDDS) represents a significant and innovative advancement in delivering poorly soluble drugs. Due to the complexity of these systems and the liquid nature of SEDDS, thorough investigation is essential. This study explored the stability of self-emulsifying (SE) pellets containing the volatile compound thymol coated with gastro-resistant Eudragit® L 30 D-55 water dispersion.
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