Chronic citalopram effects on the brain neurochemical profile and perfusion in a rat model of depression detected by the NMR techniques – spectroscopy and perfusion

• Authors: PAVLOVA Iveta; DRAŽANOVÁ Eva; KRÁTKÁ Lucie; AMCHOVÁ Petra; HRICKOVÁ Mária; MACÍČEK Ondřej; VITOUŠ Jiří; JIŘÍK Radovan; RUDÁ Jana
• Year of publication: 2024
• Type: Article in Periodical
• Magazine / Source: Biomedicine and Pharmacotherapy
• MU Faculty or unit: Faculty of Medicine
• Web: https://www.sciencedirect.com/science/article/pii/S0753332224015427
• Doi: http://dx.doi.org/10.1016/j.biopha.2024.117656
• Keywords: Citalopram; Depression; Brain metabolites; Olfactory bulbectomy; Cerebral perfusion; Rats
• Description: Collectively, 1H MRS and rCBF approaches demonstrated their capacity to capture an OB-induced phenotype and chronic antidepressant treatment effect in multiple brain regions.

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