Publication details
Gastroretentivní lékové formy v diabetologii
| Title in English | Gastroretentive dosage forms in diabetology |
|---|---|
| Authors | |
| Year of publication | 2024 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | Gastroretentive dosage forms are dosage forms that show a longer residence time in the stomach than the standard. This is a relatively diverse but innumerable group of oral pharmaceutical forms whose primary task is to overcome the physiological aspects of digestion – primarily gastric motility and gastric retention time and their variability. They are intended for administration after a meal, when the stomach volume is characterized by a multiple increase in volume and a more significant increase in pH, while depending on the type and volume of food, the stomach is emptied to its original state within 3–6 hours. Among the most fundamental mechanisms of gastroretention are the high density of the dosage form, floating systems (the opposite of high density), or expanding dosage forms. In the field of diabetology, they are mainly used as dosage forms for metformin hydrochloride, which is a drug with a narrow absorption window. Gastroretention causes metformin to be released in the stomach over a long period of time, creating a reservoir that gradually releases the drug to the places where it is to be absorbed. This work aims to present a complete picture of an often neglected issue and, due to the growing number of original and generic preparations on the market, also to compare the gastroretention abilities of selected medicinal preparations available in the Czech Republic. For this purpose, a short study was conducted using pharmaceutical technology evaluation methods (gel layer thickness, dissolution test). The results showed that not all generic preparations share the same mechanism of gastroretention, which could be a complication, e.g. in generic substitution. |