Publication details

Self-emulsifying system disrupts coat function

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Authors

MACKŮ Jan KUBOVÁ Kateřina VYSLOUŽIL Jakub MUSELÍK Jan PAVELKOVÁ Miroslava VETCHÝ David ČUBOVÁ URBANOVÁ Martina BRUS Jiří

Year of publication 2024
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

Citation
Description The study brings evidence of interference of the self-emulsifying system (SES) with the function of gastro-resistant acidoresistant excipients, resulting in disruption of the dosage form performance. So far, through the stability study the issue was identified as a change of state of the plasticizer used. However, with much better dissolution performance of no-SES caffeine control samples at the time of preparation, it is imperative to carry out detailed investigations of the individual substance’s involvement. The acquired knowledge will lead to the coat formulation suitable for dosage forms with SES.
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