Publication details
A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health
| Authors | |
|---|---|
| Year of publication | 2024 |
| Type | Article in Periodical |
| Magazine / Source | CRITICAL REVIEWS IN TOXICOLOGY |
| MU Faculty or unit | |
| Citation | MHAOUTY-KODJA, Sakina, Daniel ZALKO, Sabrina TAIT, Emanuela TESTAI, Catherine VIGUIE, Emanuela CORSINI, Nathalie GROVA, Franca Maria BURATTI, Nicolas J. CABATON, Lucia COPPOLA, de la Vieja ANTONIO, Maria DUSINSKA, El Yamani NAOUALE, Valentina GALBIATI, Patricia IGLESIAS-HERNANDEZ, Yvonne KOHL, Ambra MADDALON, Francesca MARCON, Lydie NAULE, Elise RUNDEN-PRAN, Francesca SALANI, Nicoletta SANTORI, Monica TORRES-RUIZ, Jonathan D. TURNER, Ondřej ADAMOVSKÝ, Kiara AIELLO-HOLDEN, Hubert DIRVEN, Henriqueta LOURO and Maria Joao SILVA. A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health. CRITICAL REVIEWS IN TOXICOLOGY. UNITED STATES: TAYLOR & FRANCIS LTD, 2024, vol. 54, No 10, p. 696-753. ISSN 1040-8444. Available from: https://dx.doi.org/10.1080/10408444.2024.2388712. |
| web | https://www.tandfonline.com/doi/full/10.1080/10408444.2024.2388712 |
| Doi | http://dx.doi.org/10.1080/10408444.2024.2388712 |
| Keywords | Bisphenol A alternatives; endocrine disruption; metabolism; toxicokinetic; immunotoxicity; developmental neurotoxicity; genotoxicity; carcinogenesis; human health |
| Attached files | |
| Description | Bisphenol A (BPA), a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins, has been associated with a variety of adverse effects in humans including metabolic, immunological, reproductive, and neurodevelopmental effects, raising concern about its health impact. In the EU, it has been classified as toxic to reproduction and as an endocrine disruptor and was thus included in the candidate list of substances of very high concern (SVHC). On this basis, its use has been banned or restricted in some products. As a consequence, industries turned to bisphenol alternatives, such as bisphenol S (BPS) and bisphenol F (BPF), which are now found in various consumer products, as well as in human matrices at a global scale. However, due to their toxicity, these two bisphenols are in the process of being regulated. Other BPA alternatives, whose potential toxicity remains largely unknown due to a knowledge gap, have also started to be used in manufacturing processes. The gradual restriction of the use of BPA underscores the importance of understanding the potential risks associated with its alternatives to avoid regrettable substitutions. This review aims to summarize the current knowledge on the potential hazards related to BPA alternatives prioritized by European Regulatory Agencies based on their regulatory relevance and selected to be studied under the European Partnership for the Assessment of Risks from Chemicals (PARC): BPE, BPAP, BPP, BPZ, BPS-MAE, and TCBPA. The focus is on data related to toxicokinetic, endocrine disruption, immunotoxicity, developmental neurotoxicity, and genotoxicity/carcinogenicity, which were considered the most relevant endpoints to assess the hazard related to those substances. The goal here is to identify the data gaps in BPA alternatives toxicology and hence formulate the future directions that will be taken in the frame of the PARC project, which seeks also to enhance chemical risk assessment methodologies using new approach methodologies (NAMs). |
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