Publication details

Anti-inflammatory and antioxidant activity of dibenzocyclooctadiene lignans from Schisandra chinensis

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Authors

SMIŠTÍK Ondřej RYBNIKÁŘ Michal MALANÍK Milan ŠMEJKAL Karel DALL'ACQUA Stefano JURČEK Ondřej TREML Jakub

Year of publication 2024
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

Citation
Description Some dibenzocyclooctadiene lignans have shown antioxidant activity.The highest antioxidant activity was demonstrated by (-)-gomisin J (p < 0.001). This activity corresponded to approximately 50% of the activity of quercetin (p< 0.001), which served as a positive control. The anti-inflammatory activity was detected for (-)-gomisin N (p< 0.0001) and (+)-?-schisandrin (p< 0.0001)at a concentration of 10 µM. The activity of these compounds was higher than that of the positive control prednisolone (p< 0.0001) at a concentration 2 µM.
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