Publication details
Chemistry and structural biology of 1,2-interstrand adducts of cisplatin
| Authors | |
|---|---|
| Year of publication | 2000 |
| Type | Chapter of a book |
| MU Faculty or unit | |
| Citation | |
| Description | Formation of DNA interstrand cross-links of different platinum antitumor compounds is challenging to be understood, not only from the mechanistic view, but also from the therapeutic one. Comprehension of the physiological roles of DNA interstrand cross-links of antitumor platinum compounds in functions of tumor cells requires integration of inorganic chemistry, molecular and cell biology and pharmacology. A coordinated effort in the research of interstrand cross-links induced by genotoxic agents is underway to resolve remaining problems of their structures, cellular processing and biological significance. This review article summarizes a current knowledge on structure, biochemistry and biological impact of interstrand cross-links formed in DNA by antitumor cisplatin. |