Publication details
Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates
| Authors | |
|---|---|
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Biochemistry |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Description | The requirement for novel platinum antitumor drugs led to the concept of synthesis of novel platinum antitumor complexes based on the targeting cisplatin to various carrier molecules. In order to understand the molecular mechanisms underlying the biological activity of this new class of platinum compounds, studies of modifications of synthetic oligodeoxyribonucleotide duplexes by cisplatin tethered to the oligopeptide DNA minor groove binder distamycin were initiated. The results have indicated that the attachment of distamycin to cisplatin has no essential effect on intrastrand cross-linking of the parent platinum drug between adjacent purine residues. In contrast, tethering cisplatin to distamycin affects the sites preferentially involved in the interstrand cross-links. |