Publication details
Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media
| Authors | |
|---|---|
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Biochemical Pharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Description | Modifications of natural DNA in cell-free media by antitumor ruthenium compounds, cis- and trans-[Cl2(Me2SO4)4Ru] were studied by various biochemical and biophysical methods. The results indicated that both ruthenium compounds irreversibly coordinated to DNA. Several features of DNA binding mode of trans-[Cl2(Me2SO4)4Ru] were similar to those of antitumor cisplatin, which may be relevant to biological effects of this antitumor ruthenium drug. On the other hand, the different DNA binding mode of cis-[Cl2(Me2SO4)4Ru] was consistent with its less pronounced biological effects. |