Publication details
The effects of Fos proteins on myeloid differentiation
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Proceedings |
| Conference | V. Pracovní setkání biochemiků a molekulráních biologů |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Fos |
| Description | The line of v-myb-transformed chicken monoblasts BM2 is a suitable model for study of myeloid differentiation. These cells proliferate in monoblastic stage and their terminal differentiation steps are blocked. We found that overexpression of v-fos and c-fos causes growth arrest of BM2 cells. To clarify this observation we performed cell cycle analysis. We found that c-Fos partially induces apoptosis while v-Fos rather affects cell cycle of BM2 cells. |
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