Publication details
Sledování genotoxické aktivity volatilních halogenovaných alifatických uhlovodíků
| Title in English | Detection of genotoxic activity of volatile halogenated aliphatic hydrocarbones |
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| Authors | |
| Year of publication | 2001 |
| Type | Article in Proceedings |
| Conference | V. Pracovní setkání biochemiků a molekulárních biologů |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Drosophila melanogaster; SMART test; eing spot test |
| Description | Training set of 10 compounds - 5 haloalkanes and 5 haloalkenes were selected from a group of halogenated aliphatic hydrocarbons using statistical experimental design. The chronic toxicity expressed as the lethal dose (LD50) of volatile halogenated aliphatic substances was determined in the training set for genotoxicity testing in wings (Somatic Mutation and Recombination Test) in Drosophila melanogaster. Toxicity of bromo substances was significantly higher than chloro substances. Also size of the molecules was important for toxicity. |
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