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Publication details
Aktivita cytochromu P450-2D6 a N-acetyltransferázy v izolovaných perfundovaných játrech potkana po podání agonistů 5-HT receptorů
Title in English | Activity of cytochrome P450-2D6 a N-acetyltransferase in the isolated perfused rat liver after administration of agonists of 5-HT receptors |
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Authors | |
Year of publication | 2000 |
Type | Article in Periodical |
Magazine / Source | Československá fyziologie |
MU Faculty or unit | |
Citation | |
Field | Pharmacology and pharmaceutical chemistry |
Keywords | Cytochrome P450; N-acetyltransferase; 5-HT1 agonists; rat; liver |
Description | Influence of selected agonists of 5-HT1 receptors on the activity of CYP 2D and NAT2 was followed in the isolated liver of rat donors. The results showed that RU-24969 and CGS 12066B inhibited the CYP2D activity, but they did not affect NAT2 activity. Sumatriptan slightly inhibited NAT2 activity and did not influence the oxidative metabolism in the liver. |
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