Publication details

Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder

Authors

HADAŠOVÁ Eva ŽOURKOVÁ Alexandra ZELENKOVÁ Olga

Year of publication 2001
Type Article in Proceedings
Conference International Congress 2001: "Severe Debilitating diseases". Abstract Book.
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords Pharmacogenetics; genetic polymorphism; cytochrome P 450 2D6; depressive disorder; adverse effects;
Description Adverese effects of the long-term therapy with SSRI antidepressants including sexual disorders may be more pronounced in patients with decreased activity of CYP 2D6, either given by the defect of the enzyme expression or evoked by previous treatment with enzyme inhibitors.
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