Publication details
Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha
| Title in English | Lipoxygenase metabolites are negative regulators of differentiation induced by tumor necrosis factor-alpha. |
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| Authors | |
| Year of publication | 2001 |
| Type | Article in Proceedings |
| Conference | 2nd International Scientific Conference |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Description | Tumor necrosis factor-a (TNF) is a pleiotropic cytokine. Besides other effects it promotes differentiation of leukaemic cells and activates (phosphorylates) jun-NH2-terminal kinase (JNK). JNK activation might be involved in signalling pathway leading to differentiation. MK-886 alone did not cause differentiation, however it increased non-specific esterase activity, reactive oxygen intermediates production and CD11b/CD14 cell surface antigen expression after TNF treatment, i. e. it potentiated differentiation of HL-60 cells. On the other hand indomethacin alone or in combination with TNF did not influence measured parameters of differentiation. Neither indomethacin, nor MK-886 influenced JNK activation. We concluded that endogenous LOX metabolites might play negative role in differentiation induced by TNF and that this effect is independent of JNK activation. These results may be beneficial for leukaemic patients. |
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