Publication details

BEHAVIORÁLNÍ ÚČINKY FELBAMÁTU V MODELU MYŠÍCH SOCIÁLNÍCH INTERAKCÍ

Title in English Behavioural effect of felbamate in the agonistic model of social interactions in mice
Authors

PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra

Year of publication 2002
Type Article in Periodical
Magazine / Source Psychiatrie
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords animal behaviour; antidepressant; felbamate; mouse
Description Felbamate belongs to the antiepileptic drugs of the 3rd generation, that are known for their psychotropic effects potentially usefull in the therapy of depressive patients. We studied effects of felbamate (15.0, 60.0 a 240.0 mg/kg, p.o.) on social, defence-escape, aggressive and locomotory behaviour in male mice in the agonistic interaction with the non-aggressive group-housed partners. We observed a dose dependent antiagressive effect of felbamate without sedation, further more, there was a significant stimulation of locomotion after the highest dose used.
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