Publication details
Prognostické faktory karcinomu faryngu a supraglottis
| Title in English | Prognostic factors in the pharyngeal and supraglottis carcinoma |
|---|---|
| Authors | |
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Choroby hlavy a krku ( Head and Neck Diseases) |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | head and neck carcinoma; prognosis; Ki-67; DNA; Flow cytometry |
| Description | 60 patients with the pharynx and supraglottis carcinomas were involved in statistical evaluation of survival in relation to the TNM stage, grading, kinetic parameters of a cellular cycle, Ki-67 marker and the changes of DNA ploidity in association with chemotherapy. Impaired prognosis connected with grading 1 - 2 and improved prognosis in grading 3 - 4 is evident. The effects of ploidity and Ki-67 marker on survival were statistically insignificant. A higher share of the tumor cells in S-phase has shown great probability of reaching long-term or medium-term survival. Patients with a lower share of cells in S-phase and increased occurrence of G2/M phase are in the risk of progression. |
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