Publication details
Mechanismy přestavby chromatinu
| Title in English | Mechanisms of chromatin remodeling |
|---|---|
| Authors | |
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Biologické listy |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Description | Chromatin appears to be ramarkably resistant to physical perturbation and inhospitable to molecular machines that use it as a substrate for transcription, replication, recombination, DNA repair and chromosome segregation. All of these processes are associated with chromatin remodeling increasing DNA accessibility to DNA-binding proteins. Several mechanisms have been identified that modelate chromatine structure: ATP-dependent chromatin remodeling complexes which work as machines to physically dissociate the DNA from histones and complex enzyme machinery chemically modifying histones. Histone post-translation modofications include acetylation, phosphorylation, methylation and ubiquitination, which usually take place on the tail domains of histones. Hisone modifications may alter chromatine structure by affecting histone-DNA interactions or may represent specific histone language - a "histone code" - encoded on the histone tail domains and read by other proteins or protein complexes. Chromatin remodeling is very complex process and its mechanisms are in focus of this review. |
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