Publication details
Influence of ligands of serotonin receptors on the drug-metabolizing processes in the isolated perfused rat liver
| Authors | |
|---|---|
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Bratislavské lekárské listy |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | izolated perfused liver; CYP2D1 |
| Description | The effects of selective ligands of 5-HT3 and 5-HT1A/1B receptors, tropisetrone and RU 249, on N-acetylation and cytochrome P460-mediated metabolism in the isolated perfused rat liver were followed. The study has shown significant inhibition of acetylation, but a marked stimulation of CYP 2D1 activity after administration of both substances, with higher significance in RU 24969. |
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