Publication details
Rozdílné účinky proteinů v-Fos a c-Fos na linii ptačích monoblastů transformovaných onkogenem v-myb
| Title in English | Differential effects of v-Fos and c-Fos proteins on the line of v-myb-transformed chicken monoblasts |
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| Authors | |
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Informační listy Genetické společnosti Gregora Mendela |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | Fos; Myb; apoptosis; differentiation; monoblast |
| Description | We isolated transgenic variants of BM2 cell line inducibly expressing v-fos and c-fos genes. We found that both genes induce specific phenotypic changes. v-Fos protein slows down growth of BM2 cells, induces their adherency and reduces their phagocytic activity suggesting that v-Fos stimulates partial dedifferentiation of BM2 cells to less mature stage. In contrast to v-Fos, the c-Fos protein induces apoptosis of BM2 cells. These results document that v-Fos oncoprotein cooperates with v-myb oncogene and enhances its transforming capabilites. On contrary, cellular Fos acts against the v-myb and suppresses its anti-apoptotic effects. |
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