Publication details
Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups
| Authors | |
|---|---|
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Biological Inorganic Chemistry |
| MU Faculty or unit | |
| Citation | |
| web | http://link.springer.de/link/service/journals/00775/tocs/t0005003.htm |
| Field | Biophysics |
| Keywords | DNA;cisplatin; transplatin; cross-link; dimethyl sulfate |
| Description | DNA binding studies of antitumor effective trans-platinum complexes with planar ligands have shown that they form much higher amount of interstrand cross-links than cisplatin. Interstrand cross-linking are formally equivalent to that of cisplatin but different from their direct ineffective analog, transplatin. This result shows that a simple chemical modification of the structure of inactive compound alters its DNA binding site into an addduct of active drug. |