Publication details

DNA Interactions of New Antitumor Aminophosphine Platinum (II) Complexes

Authors

NEPLECHOVÁ Kamila KAŠPÁRKOVÁ Jana VRÁNA Oldřich NOVÁKOVÁ Olga HABTEMARIAM Abraha WATCHMAN Beth SADLER Peter J. BRABEC Viktor

Year of publication 1999
Type Article in Periodical
Magazine / Source Molecular Pharmacology
MU Faculty or unit

Faculty of Science

Citation
Web http://molpharm.aspetjournals.org/
Field Biophysics
Keywords DNA; platinum complexes; modification; biophysical analysis
Description DNA binding of two novel platinum complexes was studied by biophysical methods. DNA binding manner was different from that of cisplatin. It is suggested that the activity profile of these compounds which is different from cisplatin might be associated with their specific DNA binding properties.

You are running an old browser version. We recommend updating your browser to its latest version.

More info