Publication details

A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464

Authors

MCGREGOR Tracey D. HEGMANS Alexander KAŠPÁRKOVÁ Jana NEPLECHOVÁ Kamila NOVÁKOVÁ Olga PEŇÁZOVÁ Hana VRÁNA Oldřich BRABEC Viktor FARRELL Nicholas

Year of publication 2002
Type Article in Periodical
Magazine / Source Journal of Biological Inorganic Chemistry
MU Faculty or unit

Faculty of Science

Citation
web http://link.springer.de/link/service/journals/00775/tocs/t2007004.htm
Field Biophysics
Keywords unwinding; dinuclear platinum; hydrogen bonding; cross-links
Description The dNA binding profiles of three bisplatinum polyamine-linked compounds were compared with that of antitumor efficient trisplatinum compound BBR3464. It was found that their binding manner is similar.

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