Publication details

Effect of mirtazapine and paroxetine on residual symptoms of depressive disorders and their effect on P450 CYP 2D6 activity

Authors

ŽOURKOVÁ Alexandra

Year of publication 2001
Type Article in Periodical
Magazine / Source Homeostasis
MU Faculty or unit

Faculty of Medicine

Citation
Field Psychiatry, sexuology
Keywords depressive disorder-residual symptoms-CYP 2D6-poor metaboliser-extensive metaboliser
Description The issues related to preventing a relapse of depressive disorder are high on the list of priorities of psychiatry.The achievement of only a partial remission is a predictor of a higher incidence of relapses.30 patients displaying residual symptoms of depressive disorder were treated with paroxetine or mirtazapine in the conditions of a double-blind study involving monitoring CYP 2D6 activity.Both mirtazapine and paroxetine had a positive effect on residual symptoms of depressive disorder.
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