Publication details
Realtionship betwen K-ras mutation and the expression of p21 WAF1/CIP1 and p53 in chronic pankreatitis and pancreatic adenocarcinoma
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Neoplasma |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | Pancreatic intraepihedial neoplasia; K-ras; p21WAF1/CIP1; p53 |
| Description | Overexpression of p21WAF1/CIP1wasrecently discribed as an early event in the development of pancreatic intraepihelial neoplasia. Since activating K-ras mutation are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the posible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated in our study. |
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