Publication details
Felbamát působí u myší behaviorální a humorální změny ukazující na jeho antidepresivní aktivitu
| Title in English | Felbamate is inducing behavioural and hormonal changes in mice indicating its antidepressant activity |
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| Authors | |
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Československá fyziologie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | felbamate; stress hormones; depression; agonistic interactions; mice |
| Description | The hypothesis that felbamate (FBM), an antiepileptic drug with antiglutamatergic action, reduces responses to stress of social conflict was verified. FBM failed to modify catecholamines, but enhanced corticosterone levels. Repeated agonistic interactions with an aggressive mouse increased corticosterone and dopamine release. FBM inhibited these changes without causing sedation. FBM reduced aggression in aggressive mice. After repeated stress, acute FBM prevented depression-like behavior in open field. The data suggest that glutamate is involved in behavioral and hormonal changes due to social stress and support clinical reports on potential antidepressant action of FBM. |
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