Publication details

INFLUENCE OF CANNABINOID RECEPTOR CB1 AGONIST ACPA AND CB2 AGONIST JWH 015 ON MOUSE LEUKOCYTE PHAGOCYTOSIS

Authors

VINKLEROVÁ Jana ŠULCOVÁ Alexandra

Year of publication 2003
Type Article in Periodical
Magazine / Source Homeostasis in Health and Diseases
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords cannbainoids - CB1 receptor - CB2 receptor - leukocyte phagocytosis
Description The effects of selective CB2 receptor agonist JWH 015 resembled the biphasic effect of the mixed CB1,2 agonists - endocannabinoid anandamide and a synthetic agent HU 210 (Vinklerová J, 2000 and 2001 and 2002)found earlier: a significant increase of leukocyte phagocytic activity at low doses and a decrease at higher doses. On the contrary CB1 receptor agonist ACPA produced just a significant decrease of leukocyte phagocytosis in the present study. These results clearly show that CB2 receptor activation is able to produce both immunostimulation and immunosuppression depending on the dose used. An involvement of CB1 receptors should be studied further using doses lower than in this study.
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