Publication details

Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts

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Authors

ZAHRADNÍČKOVÁ Eva ŠEVČÍKOVÁ Sabina SOUČEK Karel ŠMARDA Jan

Year of publication 2003
Type Article in Proceedings
Conference Memory in Living Systems
MU Faculty or unit

Faculty of Informatics

Citation
Field Genetics and molecular biology
Keywords Fos; Myb; proliferation; differentiation; apoptosis
Description c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell.
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