Publication details
Type II iodothyronine 5'-deiodinase and uncoupling protein in brown adipose tissue of human newborns
| Authors | |
|---|---|
| Year of publication | 1993 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Clinical Endocrinology and Metabolism [IF=4.220 (1992); SCI #cit.<30>] |
| MU Faculty or unit | |
| Citation | |
| Field | Paediatry |
| Keywords | Brown adipose tissue; human newborn; iodothyronine deiodinase; uncoupling protein |
| Description | Brown adipose tissue (BAT) from 13 newborns of 25-40 weeks gestational age who survived 4 days, at most, was investigated. BAT was found to contain significant amounts of the mitochondrial uncoupling protein (UCP), the rate-limiting component of heat production. BAT was also found to contain iodothyronine 5'-deiodinase (5'D), which appears to be a type II enzyme. The development of 5'D activity was similar to the changes in UCP content; both exhibited a major increase before 32 weeks gestation. The results indicate that thermogenic function and 5'D activity develop in human BAT rather early, during the first half of the last trimester of gestation. |