Publication details
Derivatisation of peptides with osmium tetroxide, 2,2-bipyridine: capillary electrophoretic and MALDITOF mass spectrometric study
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Analytica Chimica Acta |
| MU Faculty or unit | |
| Citation | |
| Field | Analytic chemistry |
| Keywords | Peptide derivatisation; Osmium tetroxide; Bipyridine; CZE; MALDI-TOF MS; PSD |
| Description | Site-specific chemical modification is a useful technology in characterisation of proteins, but the number of chemical probes of the protein structure reacting with proteins under mild conditions in aqueous solutions is rather limited. Here we studied the reaction of osmium tetroxide, 2,2-bipyridine (Os,bipy) with several peptides using capillary zone electrophoresis (CZE) and matrix-assisted laser desorption-ionisationCtime-of-flight mass spectrometry (MALDICTOF MS). |