Publication details
Neurologické měkké příznaky u schizofrenie
| Title in English | Neurological soft signs in schizophrenia |
|---|---|
| Authors | |
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Česká a Slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | neurological soft signs; schizophrenia; first-episode schizophrenia; symptoms; outcome; cognitive dysfunction |
| Description | problemns of soft signs ián schizophrenia are summarized, special attention is devoted to neurological soft signs (NSS)in the first-episode schizophrenia. Out of many possibilities how to measure NSS, Neurological Evaluation Scale is most commonly used in psychiatric population. NSS are significantly more frequent in patietnes with schizophrenia than innormal population. The range of NSS frequency is broad and related to the metjhods used amd criteria of evaluation. NSS are present in the initial phase of illness. They are not significantly associated with administration of antipsychotics, but antipsychotics can partiallly influence its prevalence. The occurrence of NSS most frequently correlates with cognitive dyfunction and negative symptoms. Patients with NSS have a worse prognosis. The evaluation of NSS in the initial phase of illness can contribute to the identification of subjects with bad prognosis, who, can profit from early intervention and targeted pharmacotherapy ( for example sith some atypical antipsychotic drugs). The evaluation should be uniform and bilateral. In the future it will be necessary to integrate the knowledge about NSS with date from brain imaging studies and elucidate the role of NSS as a potential marker of cognitive dysfunction. |
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