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Testování bradykardického účinku nově syntetizovaných potenciálních ultrakrátkých beta blokátorů na laboratorním potkanovi
Title in English | Testing the bradycardiac effect of newly synthesized potential ultrashort beta-blockers on the laboratory rat |
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Authors | |
Year of publication | 2004 |
Type | Article in Periodical |
Magazine / Source | Česká a slovenská farmacie |
MU Faculty or unit | |
Citation | |
Field | Pharmacology and pharmaceutical chemistry |
Keywords | bradycardiac effect; rat; ultrashort beta blockers |
Description | We tested changes in heart rate induced by three newly synthesized potential ultrashort beta-blockers in normotensive laboratory Wistar rats. In all three substances tested, a statistically demonstrable short-time bradycardiac effect was observed. In all three substances tested, marked changes in the ECG record were observed immediately after administration. |