Publication details
VALIDATION OF A CAPILLARY ZONE ELECTROPHORESIS METHOD FOR DETERMINATION OF RIMANTADINE HYDROCHLORIDE IN RIMANTADIN100 TABLETS AND THE METHOD APPLICATION TO DISSOLUTION TEST MONITORING
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY |
| MU Faculty or unit | |
| Citation | |
| Field | Analytic chemistry |
| Keywords | capillary zone electrophoresis |
| Description | A capillary zone electrophoretic method with indirect UV-detection for determination of rimantadine, an antiviral drug against influenza A, in tablets was validated. Instrumental precision, the method precision, accuracy, calibration curve linearity, selectivity, robustness and time stability of the sample and the standard were tested. The method was also applied to monitor dissolution tests of the tablets. The possibility of internal standard for improvement of method precision was discussed. |
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