Amplification and overexpression of HER-2/neu in invasive ductal carcinomas of the pancreas and pancreatic intraepithelial neoplasms and the relationship to the expression of p21(WAF1/CIP1)

• Authors: HERMANOVÁ Markéta; LUKÁŠ Zdeněk; NENUTIL Rudolf; BRÁZDIL Jan; KROUPOVÁ Iva; KŘEN Leoš; PAZOURKOVÁ Marie; RŮŽIČKA Miloš; DÍTĚ Petr
• Year of publication: 2004
• Type: Article in Periodical
• Magazine / Source: Neoplasma
• MU Faculty or unit: Faculty of Informatics
• Field: Oncology and hematology
• Keywords: adenocarcinoma; pancreas; HER-2/neu; p21; immunohistochemistry; FISH
• Description: Overexpression of p21(WAF1/CIP1)seems to be HER-2/neu independent based on our results. Expression of HER-2/neu is growing according to grade of the ductal lesion and overexpression of HER-2/neu was demonstrated in 18% carcinomas. Two of 9 carcinomas with overexpression of HER-2/neu showed the amplification of HER-2/neu.