Publication details

Behavioural sensitization to methamphetamine stimulatory effects on locomotion: comparative study in mice and rats

Authors

LANDA Leoš ŠLAIS Karel HANESOVÁ Mariana ŠULCOVÁ Alexandra

Year of publication 2005
Type Article in Periodical
Magazine / Source Behavioural Pharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; mice; rats; open field; methamphetamine
Description In the Experiment 1, the significant stimulatory MET effects on mouse locomotion were apparent after the first dose (2.5 mg/kg), and the significantly increased effect was measured after the repeated administration. In the Experiment 2, MET at the doses of 2.5 or 5 mg/kg stimulated ambulation of rats in the open field test, however after the repeated administration these effects were decreased (insignificantly after the lower and significantly after the higher dose), however, in both groups stereotypic nose rubbing occurred (stereotypies are defined as one of possible signs of behavioural sensitization, too). In the Experiment 3, the significant stimulatory effect on ambulation of rats measured after the first dose of MET at the dose of 0.5 mg/kg was significantly higher after the 8th dose.
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