Publication details
Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | European Neuropsychopharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | olfactory bulbectomy; depression; tiagabine; amisulpride; rat; animal model |
| Description | The purpose of the study was to test endocrine and immune effects of antiepileptic drug tiagabine (TGB) and atypical neuroleptic amisulpride (AMS) in the well established animal model of depression bilateral olfactory bulbectomy (OB) in rats. The tested drugs elicited changes that resemble those seen following chronic treatment with clinically used antidepressants. Thus, they support further the clinical reports that TGB and AMS in addition to their antiepileptic/antipsychotic efficacy respectively may possess also antidepressant activity. |
| Related projects: |