Publication details

Effect of fluoxetine on methamphetamine biodegradation in methamphetamine dependence

Authors

JUŘICA Jan DOSTÁLEK Miroslav PISTOVČÁKOVÁ Jana TOMANDL Josef LINHART Igor ŠULCOVÁ Alexandra HADAŠOVÁ Eva

Year of publication 2005
Type Article in Periodical
Magazine / Source European Neuropsychpharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords metamphetamine; fluoxetine; dependence; pharmacokinetics
Description Fluoxetine and the combined treatment with methamphetamine inhibited oxidative metabolism by the CYP2C6 and CYP2D2 and CYP3A1/2. Fluoxetine therapy could slow down biodegradation of methamphetamine in methamphetamine dependent subjects and thus the psychotropic effect of the drug can be maintained by smaller doses.
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