Effect of fluoxetine on methamphetamine biodegradation in methamphetamine dependence

• Authors: JUŘICA Jan; DOSTÁLEK Miroslav; PISTOVČÁKOVÁ Jana; TOMANDL Josef; LINHART Igor; ŠULCOVÁ Alexandra; HADAŠOVÁ Eva
• Year of publication: 2005
• Type: Article in Periodical
• Magazine / Source: European Neuropsychpharmacology
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: metamphetamine; fluoxetine; dependence; pharmacokinetics
• Description: Fluoxetine and the combined treatment with methamphetamine inhibited oxidative metabolism by the CYP2C6 and CYP2D2 and CYP3A1/2. Fluoxetine therapy could slow down biodegradation of methamphetamine in methamphetamine dependent subjects and thus the psychotropic effect of the drug can be maintained by smaller doses.

Related projects

• Plasticity of Regulatory Mechanisms of the Central Nervous Systems