Using of electrochemical methods for studying of metallothionein content in the human blood serum of a patient poisoned by lead and treated by platinum.

• Authors: PETRLOVÁ Jitka; BLAŠTÍK Ondřej; PRŮŠA Richard; KUKAČKA Martin; POTĚŠIL David; MIKELOVÁ Radka; ADAM Vojtěch; ZEHNÁLEK Josef; KIZEK René
• Year of publication: 2005
• Type: Article in Periodical
• Magazine / Source: Biomedical Papers
• MU Faculty or unit: Faculty of Science
• Field: Electrochemistry
• Keywords: Metallothionein; Brdicka reaction; Peak H; Catalytic hydrogen reaction; Cancer; Lead; Differential pulse voltammetry; Adsorptive stripping voltammetry
• Description: Metallothioneins belong to the group of intracellular, high molecular and cysteine-rich proteins whose content increase with increasing concentration of a heavy metal. Here we applied the adsorptive transfer stripping differential pulse voltammetry Brdicka reaction for the determination of metallothionein in human blood serum of patient poisoned by lead and/or treated by platinum. The increased metallothionein concentrations in both cases were observed.

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