Comparing genomes of pathogenic and non-pathogenic spirochetes: DNA-microarray hybridizations, whole genome fingerprinting and DNA sequencing.

• Authors: ŠMAJS David; MATĚJKOVÁ Petra; STROUHAL Michal; NORRIS S.J.; WEINSTOCK G.M.
• Year of publication: 2005
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Genomes of closely related treponemes, Treponema pallidum ssp. pallidum (strains Nichols and SS14) and Treponema pallidum ssp. pertenue (Samoan D) were compared with the genome of Treponema paraluiscuniculi (strain Cuniculi A) using comparative genomic techniques. T. pallidum ssp. pallidum is the causative agent of highly invasive human disease syphilis, T. pallidum ssp. pertenue is the causative agent of yaws and T. paraluiscuniculi is not pathogenic to humans. When compared to Nichols genome, 1, 8 and 34 differences in the BamH I target restriction sites and 3, 7 and 20 indels were found in the genome of SS14, Samoan D and T. paraluiscuniculi, respectively.

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