Publication details
A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | MSF is a truncated (70kDa) isoform of fibronecting displaying number of potent biactivities mediated by IGD-amino acid motif. Two MSF isoforms, differing in terms of 15 amino acid deletion in a module II-1, have been identified. While IGD-mediated bioactivities od both isoforms are identical, deleted isoform (MSF-aa) is not inhibited by recently characterised inhibitor produced by normal keratinocytes. Furthermore, various cancer cell lines produce MSF activity which is not inhibited or partly inhibited by MSF inhibitor. |
| Related projects: |