Publication details
Studying of an interaction of flavonoids with nucleic acids
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Toxcon 2006; 11. Interdisciplinary Slovak - Czech Toxicological Conference |
| MU Faculty or unit | |
| Citation | |
| Field | Electrochemistry |
| Keywords | Electrochemistry; Flavonoids; Nucleic acidst; cytochromes P450; carbon paste electrode; Square Wave Voltammetry; |
| Description | Flavonoids comprise a wide-ranging group of plant phenols and belong to secondary plant metabolites. Up to now, more than 4,000 of flavonoid compounds have been discovered. Flavonoids are derived from heterocyclic oxygen compound, flavan, which is formed by two benzene rings linked by heterocyclic pyran. All three rings could be substituted by hydroxy- or methoxy-groups and particular derivates differs only in degree of substitution and oxidation. Natural flavonoids occur mostly in form of O-glycoside as same as many others plant compounds. It was observed that concentration of free aglycones could increase in specific conditions, to be specific, during technological processing at high temperatures and also in acidic medium in gastro-intestinal tract, when hydrolysis of glycosides may proceed. Flavonoids have a wide range of roles and functions including responsibility for colour of flowers, fruits and seeds, which helps to expansion of a plant specie. They are also important during maturation of seeds, play important role during polar transport of nutrients and element in a plant and affect protective mechanism of plants against fungal parasites. Due to that they are abundant and contained in many of plant species, flavonoids have to be part of human food and animal feed. Thus, we can say that they have a secondary function. Different effects of flavonoids have been shown: antimicrobial, spasmolytic, anticoagulant, antiestrogenic, antiinflammatory (digestive tract) etc, but the most investigated ones is their anti-oxidative effect. They can scavenge reactive oxygen species and can protect LDL fractions of lipids against their oxidative modification (crucial during atherosclerosis progress). The link between flavoniods and tumour diseases is one of other wide field of study. Many papers and reviews show that these compounds could have anti-tumour effect. Polyhydroxylation of flavonoids has been described as the most probable effect of them leading to decrease of tumour occurrence. These presumptions have been proved in in vitro, but the same effect has not been shown during in vivo experiments yet. On the other hand other recent studies have shown that some flavonoids can increase risk of tumour diseases. These flavonoids (e.g. synthetic â-naphthoflavon, diosmin) can induce intensively cytochromes p450 1A1 in intestine after peroral uptake. The induced cytochromes, which are highly inducible, participate in activation of carcinogens such as PAH. It could be expected that initiation and progression phase of cancer can be influenced through regulation of metabolic activity of cytochemoes P450 by inhibitors of this compound. Field of chemo-prevention and chemotherapy of tumour diseases of intestine is not clear yet except a few cases of using of cytochromes P450 inhibitors and natural chemo-prevention compounds of green tea, garlic etc. |