Publication details
Genetické a elektrofyziologické pozadí vnímání tinnitu u pacientů s kochleární percepční poruchou sluchu
| Title in English | Genetic and Electophysiologic Background of Tinnitus Perception in Patients with Cohlear Perception Disorder of Hearing |
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| Authors | |
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Otolaryngologie a foniatrie |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | tinnitus BAEP MLR disinhibition genetic polymorhism GABA-A receptor |
| Description | A population of 105 patients was examined on the manifestation of tinnitus. During the examination the BAEP and MLR measurings were taken, and the analysis of nine genetic polymorphisms was carried out: Taq I polymorphism of the DRD2 receptor, two polymorphisms of the gene for the subunit GRIN2a, and the 2664 C/T polymorphism of the gene for GRIN2b subunit of the NMDA receptor, CA repetitive sequence in the gene for GABRß3 subunit for GABA-A receptor. The following relations were discovered: the manifestation of tinnitus correlated with the ratio of the amplitudes of V/III waves (p<0,001), and with the amplitude of the PA wave of the MLR (p<0,001). The manifestation of tinnitus also depended on the genotype of the CA repetitive sequence of the gene for GABRß3 sub-unit (p=0,04). |