Publication details
Nukleofilní adice na protoberberinový a benzofenanthridinový skelet
| Title in English | Nucleophilic addition to protoberberine and benzophenanthridine skeleton |
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| Authors | |
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Chemické listy |
| MU Faculty or unit | |
| Citation | |
| Field | Organic chemistry |
| Keywords | protoberberine alkaloids;benzophenanthridine alkaloids; nucleophilic addition;N-nucleophiles; biological activity |
| Description | Quaternary protoberberine QPA and benzo[c]phenanthridine QBA alkaloids belong into isoquinoline alkaloids which is part of big group of secondary metabolites. QPA and QBA are characterized by significant biological activity. They can interact with nucleic acids and proteins and display a great variety of pharmacological effects, e.g. antimicrobial, antifungal, anti-inflammatory, antimalarial or cytotoxic. Both of the alkaloids are characteristic by the sensitivity of the polar C=N+ bond to a nucleophilic attack followed by the formation of adducts with substituents at position C-8 or at position C-6. |
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