HPLC STANOVENÍ MIDAZOLAMU A JEHO METABOLITŮ V PLAZMĚ A PERFUZNÍM MEDIU

• Title in English: HPLC determination of midazolam and its metabolites in plasma and perfuse medium
• Authors: JUŘICA Jan; TOMANDL Josef; DOSTÁLEK Miroslav; ZAHRADNÍKOVÁ Lucia; ZENDULKA Ondřej; HADAŠOVÁ Eva
• Year of publication: 2006
• Type: Article in Proceedings
• Conference: Zborník vedeckých prác XIV. medzinárodné konferencie Chromatografické metódy a zdravie človeka
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: HPLC; determination; CYP3A; midazolam
• Description: The presented HPLC isocratic method allows to determine midazolam and its three hydroxylated metabolites in plasma and perfusion medium. This method is suitable for modeling and description of possible pharmacological interactions on isoform CYP3A4/5.

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