Publication details
Glutamatergics and addiction
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Homeostasis in Health and Diseases |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | addiction; glutamte; memantine; phenytoin; mice;rats |
| Description | The noncompetitive NMDA receptor antagonist memantine did not produce significant alteration of sensitization either to methamphetamine stimulatory effects on mouse locomotor/exploratory behaviour in the open field test or to methamphetamine inhibitory antiaggressive effects in singly-housed mice on dyadic social interactions with non-aggressive group-housed partners. Blockade of glutamate release by treatment with phenytoin (not changing locomotor behaviour in the open field test) prevented the development of compulsory wheel running - an animal model of excercise addiction in humans. |
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