Publication details
Predictive parameters of the head and neck carcinomas
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Otolaryngologie a foniatrie, supplementum 1 |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | Head & neck cancer – risk prognosis – mitotic/apoptotic index – MMP-9 - bcl-2 – DNA cytometry |
| Description | The analysis was carried out with a set of 217 patients suffering from carcinoma of the pharynx and larynx treated at the Clinic of Otorhinolaryngology and Head and Neck Surgery in Brno within 1990 – 2005. Besides routine examinations flow cytometric analysis of DNA, mitotic, apoptotic indices, immunohistochemical determination of Ki-67, EGFR, c-erbB-2, MMP-9, p53, bcl-2, CD 34 were performed. Measure of realized proliferation (mitotic activity) significantly contributed to the risk prediction both in EFS and OS. The other cytokinetic parameters (SPF, KI-67) increased significantly relative risk only in the case of event-free survival. Cytokinetic parameters generally strongly correlated with grade score and can be thus regarded and grade correlates, responsible for the increasing risk in combination with the other risk factors like clinical stage and/or ploidy. Apoptosis did not contribute to the prediction of EFS and OS as single factor although decreased apoptic rate was significantly associated with aneuploid cells. Positivity of EGFR, c-erbB-2, CD34, p53 did not reached statistically significant value in association to EFS or OS. Positivity in bcl-2 and MMP-9 was significantly related to overall survival of patients (not to event-free survival). |